The objective of the Colloquium is to bring together researchers amongst the computational and experimental mechanics and biomechanics community to exchange the latest achievements as well as recent research work in the field of bone mechanical research. The Colloquium shall provide state-of-the-art information in the domain of bone mechanics, focusing on bone remodeling and bone adaptation as a core topic.
A bone has the ability to adapt its external shape and internal structure to variations in its mechanical environment. The adaptive response of bones to changes in load history is called bone remodeling since the pioneering work of Wolff (1892): adaptation of bone to functional demands such as mechanical loadings may result in bone loss in situations of reduced loading, and bone mass increase in situations when functional mechanical loadings exceed a certain magnitude.
Despite the many studies devoted to the mechanisms controlling the process of bone formation and renewal, a clear understanding of the underlying mechanisms across the scales and the role of mechanical loading is still not available. Bone is multiscale in nature and the tissue integrity is maintained across large length and time scales by complex multiscale multiphysical homeostatic processes regulated by specialized cells. Since these are difficult to identify based purely on experiments, it is important to develop multiscale computational approaches in combination with the acquisition of new experimental data obtained by efficient imaging techniques to integrate and investigate these processes.
Optimization theories envisage bone as a mechanical structure undergoing an evolutionary adaptation, and will be one important topic of the Colloquium. Application of the computational models to predict the impact of medical treatments and implants in a patient-specific based approach is another important topic covered by the Colloquium.
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